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NRT: Although co-administration of varenicline (1 mg twice daily) and transdermal nicotine (21 mg/day) for up to 12 days did not affect nicotine pharmacokinetics, the incidence of adverse reactions was greater for the combination than for NRT alone [see Drug Interactions (7.1)]

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Tarran, who is a member of the UNC Lineberger Comprehensive Cancer Center, and colleagues measured levels of three key protease enzymes in lung fluid sampled from 41 subjects nonsmokers, smokers, and vapers